The presence of light-chains specific free K/λ in urine may be an indication of a mono-or polyclonal gammapathy. This pathology, called Bences Jones Proteinuria, is characterized by the indiscriminate proliferation of B-cell lymphocytes which are detectable in the urine as free K & λ proteins. The pathology is associated with Multiple Myeloma, Waldenström’s Macroglobulinemia, monoclonal light chain amiloidosis, and light chain deposition disease.
PRINCIPLE OF METHOD
The ASTRA Dipstick Bence Jones Free K/λ kit is a competitive, immuno-chromatographic assay, based on lateral flow nitrocellulose membrane technology. The assay has 3 reaction zones without prozone effect:
1. The first zone (closest to dipstick tab) represents the procedural control (CP).
2. The second zone (middle) line striped with free λ antigens.
3. The third zone (lowest) line striped with free Κ antigens.
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